How Opioid Antagonists Reduce the Craving for Alcohol
David Sinclair, Roy Eskapa and Michael Sinclair
Oct 13, 2014
There is a widespread misunderstanding about how and when opioid antagonists such as naltrexone, naloxone, and nalmefene, suppress the craving for alcohol. The preclinical and clinical evidence reviewed here show that craving is not reduced simply by the presence of the antagonists in the body. Instead, they work by the mechanism of extinction. Alcohol drinking is learned through reinforcement involving the opioid system.
Drinking alcohol while an opioid antagonist blocks the reinforcement starts extinction of the drinking behavior and craving.
Read the full review below or download here.