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Scientific Information on The Sinclair Method, Naltrexone and Nalmefene
Peer-reviewed Research and Writings by J. David Sinclair, PhD
The Sinclair Method definitive statement

Sinclair, J.D. and R.J. Senter. Increased preference for ethanol in rats following alcohol deprivation. Psychonomic Science 8: 11‑12, 1967.

Sinclair, J.D. The alcohol‑deprivation effect: Influence of various factors. Quarterly Journal of Studies on Alcohol 33: 769‑782, 1972.

Sinclair, J.D. Rats learning to work for alcohol. Nature 249: 590‑592, 1974.

Sinclair, J.D., J.Adkins, and S.Walker. Morphine‑induced suppression of voluntary alcohol drinking in rats. Nature 246: 425‑427, 1973.

Sinclair, J.D. Method for Treating Alcohol‑Drinking Response. USA patent  4,882,335 Nov. 21, 1989.

Sinclair, J.D. Drugs to decrease alcohol drinking. Annals of Medicine 22: 357‑362, 1990.

Sinclair, J.D. Evidence about the use of naltrexone and for different ways of using it in the treatment of alcoholism. Alcohol and Alcoholism, 36: 2-10, 2001.

How Opioid Antagonists Reduce the Craving for Alcohol, by David Sinclair, Roy Eskapa and Michael Sinclair 
Peer-reviewed Studies
Kranzler, H. R., Tennen, H., Armeli, S., Chan, G., Covault, J., Arias, A., & Oncken, C. (2009). Targeted naltrexone for problem drinkers. Journal of Clinical Psychopharmacology, 29(4), 350–357. http://doi.org/10.1097/JCP.0b013e3181ac5213
Heinälä, P., H. Alho, K. Kiianmaa, J. Lönnqvist, K. Kuoppasalmi, and J. D. Sinclair. Targeted use of naltrexone without prior detoxification in the treatment of alcohol dependence: A factorial double-blind placebo-controlled trial. Journal of Clinical Psychopharmacology: 21(3): 287-292, 2001.
Grant BF, Goldstein RB, Saha TD, et al. Epidemiology of DSM-5 Alcohol Use Disorder: Results From the National Epidemiologic Survey on Alcohol and Related Conditions III. JAMA Psychiatry. Published online June 03, 2015. doi:10.1001/jamapsychiatry.2015.0584.
Jonas DE, Amick HR, Feltner C, et al. Pharmacotherapy for Adults With Alcohol Use Disorders in Outpatient Settings: A Systematic Review and Meta-analysis. JAMA. 2014;311(18):1889-1900. doi:10.1001/jama.2014.3628.
The COMBINE Study—An Overview of the Largest Pharmacotherapy Study to Date for Treating Alcohol Dependence Psychiatry (Edgmont). Oct 2006; 3(10): 36–39.
Concurrent Naltrexone and Prolonged Exposure Therapy for Patients With Comorbid Alcohol Dependence and PTSDA Randomized Clinical Trial JAMA. 2013;310(5):488-495. doi:10.1001/jama.2013.8268
Darren R. Quelch et al. Nalmefene Reduces Reward Anticipation in Alcohol Dependence: An Experimental Functional Magnetic Resonance Imaging Study, Biological Psychiatry (2017). DOI: 10.1016/j.biopsych.2016.12.029
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Annotated Bibliography for Physician
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BNSSG Health Community’s Traffic Light System
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Evidence About the Use of Naltrexone
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2012 European Congress of Psychiatry on Selincro™
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ClinicalTrials.gov Keyword: "naltrexone alcoholism"