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Scientific Information on The Sinclair Method, Naltrexone and Nalmefene

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Peer-reviewed Research and Writings by J. David Sinclair, PhD
The Sinclair Method definitive statement

Sinclair, J.D. and R.J. Senter. Increased preference for ethanol in rats following alcohol deprivation. Psychonomic Science 8: 11‑12, 1967.

Sinclair, J.D. The alcohol‑deprivation effect: Influence of various factors. Quarterly Journal of Studies on Alcohol 33: 769‑782, 1972.

Sinclair, J.D. Rats learning to work for alcohol. Nature 249: 590‑592, 1974.

Sinclair, J.D., J.Adkins, and S.Walker. Morphine‑induced suppression of voluntary alcohol drinking in rats. Nature 246: 425‑427, 1973.

Sinclair, J.D. Method for Treating Alcohol‑Drinking Response. USA patent  4,882,335 Nov. 21, 1989.

Sinclair, J.D. Drugs to decrease alcohol drinking. Annals of Medicine 22: 357‑362, 1990.

Sinclair, J.D. Evidence about the use of naltrexone and for different ways of using it in the treatment of alcoholism. Alcohol and Alcoholism, 36: 2-10, 2001.

How Opioid Antagonists Reduce the Craving for Alcohol, by David Sinclair, Roy Eskapa and Michael Sinclair 
Peer-reviewed Studies
Kranzler, H. R., Tennen, H., Armeli, S., Chan, G., Covault, J., Arias, A., & Oncken, C. (2009). Targeted naltrexone for problem drinkers. Journal of Clinical Psychopharmacology, 29(4), 350–357. http://doi.org/10.1097/JCP.0b013e3181ac5213

Heinälä, P., H. Alho, K. Kiianmaa, J. Lönnqvist, K. Kuoppasalmi, and J. D. Sinclair. Targeted use of naltrexone without prior detoxification in the treatment of alcohol dependence: A factorial double-blind placebo-controlled trial. Journal of Clinical Psychopharmacology: 21(3): 287-292, 2001.

Grant BF, Goldstein RB, Saha TD, et al. Epidemiology of DSM-5 Alcohol Use Disorder: Results From the National Epidemiologic Survey on Alcohol and Related Conditions III. JAMA Psychiatry. Published online June 03, 2015. doi:10.1001/jamapsychiatry.2015.0584.

Jonas DE, Amick HR, Feltner C, et al. Pharmacotherapy for Adults With Alcohol Use Disorders in Outpatient Settings: A Systematic Review and Meta-analysis. JAMA. 2014;311(18):1889-1900. doi:10.1001/jama.2014.3628.

The COMBINE Study—An Overview of the Largest Pharmacotherapy Study to Date for Treating Alcohol Dependence Psychiatry (Edgmont). Oct 2006; 3(10): 36–39.

Concurrent Naltrexone and Prolonged Exposure Therapy for Patients With Comorbid Alcohol Dependence and PTSDA Randomized Clinical Trial JAMA. 2013;310(5):488-495. doi:10.1001/jama.2013.8268

Darren R. Quelch et al. Nalmefene Reduces Reward Anticipation in Alcohol Dependence: An Experimental Functional Magnetic Resonance Imaging Study, Biological Psychiatry (2017). DOI: 10.1016/j.biopsych.2016.12.029
Information from government agencies
SAMHSA - Evidence for the Efficacy of Naltrexone in the Treatment of Alcohol Dependence (Alcoholism)

The National Center for Biotechnology Information: Incorporating Alcohol Pharmacotherapies Into Medical Practice

The Scottish Medicines Consortium (SMC) advice to NHS Boards and Area Drug and Therapeutic Committees (ADTCs) on its use in Scotland
News and Trade Publications
The Fix - Is Naltrexone an Ineffective Treatment for Alcoholism? Or are we just using it the wrong way?

Medical Xpress - Window to brain's reward system could lead to better treatments for alcoholism

Current Psychiatry - Medication for alcohol use disorder: Which agents work best?

Selincro(TM) (nalmefene) receives positive opinion for approval in the European Union
Downloads
Annotated Bibliography for Physician
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BNSSG Health Community’s Traffic Light System
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Evidence About the Use of Naltrexone
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2012 European Congress of Psychiatry on Selincro™
File Size: 147 kb
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ClinicalTrials.gov Keyword: "naltrexone alcoholism"
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